MYELOID NEOPLASIA An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model

نویسندگان

  • Rachel J. Bergerson
  • Lara S. Collier
  • Aaron L. Sarver
  • Raha A. Been
  • Sanne Lugthart
  • Miechaleen D. Diers
  • Johannes Zuber
  • Amy R. Rappaport
  • Molly J. Nixon
  • Kevin A. T. Silverstein
  • Danhua Fan
  • Anne-Francoise J. Lamblin
  • Linda Wolff
  • John H. Kersey
  • Ruud Delwel
  • Scott W. Lowe
  • M. Gerard O’Sullivan
  • Scott C. Kogan
  • David J. Adams
  • David A. Largaespada
چکیده

1Department of Genetics, Cell Biology and Development and Department of Pediatrics, Masonic Cancer Center, University of Minnesota Twin Cities, Minneapolis, MN; 2Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, WI; 3Biostatistics and Bioinformatics, Masonic Cancer Center, University of Minnesota Twin Cities, Minneapolis, MN; 4Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands; 5Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; 6Watson School of Biological Sciences, Cold Spring Harbor, NY; 7Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Bethesda, MD; 8Howard Hughes Medical Institute, Cold Spring Harbor, NY; 9Comparative Pathology Shared Resource, Masonic Cancer Center, University of Minnesota Twin Cities, Minneapolis, MN; 10Department of Laboratory Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA; and 11Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model.

Patients with a t(9;11) translocation (MLL-AF9) develop acute myeloid leukemia (AML), and while in mice the expression of this fusion oncogene also results in the development of myeloid leukemia, it is with long latency. To identify mutations that cooperate with Mll-AF9, we infected neonatal wild-type (WT) or Mll-AF9 mice with a murine leukemia virus (MuLV). MuLV-infected Mll-AF9 mice succumbed...

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تاریخ انتشار 2012